The MSP post in Paw Paw also says several others have been injured in the pileup that occurred in near white-out conditions. At last check, 23 drivers were transported to hospitals in Kalamazoo and Battle Creek.
WATCH: Watch the amateur video above to see the chain reaction of the accident. Explicit language is used at one point.
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The crash occurred Friday morning near the 90 mile marker on I-94. Police say the pileup occurred just after 10 a.m. A FOX 2 viewer, however, says the crash occurred shortly after 9 a.m. while he was on his way to work.
Police say approximately 50-70 vehicles were involved in the initial accident, and a continuing chain reaction has now involved 123 vehicles. The cars are piled up on both the westbound and eastbound sides.
Police say they are aware of four semi trucks and two cars that caught fire.
A three-mile radius was briefly evacuated Friday afternoon due to a burning semi truck containing hazardous material. A hazmat team has been on site evaluating the situation.
Another of the burning semi trucks was carrying around 40 pounds of fireworks. John Rudolph, a truck driver from Ypsilanti, sent us a photo of the smoke from that fire, saying it was so thick you could barely see through it. Police say that truck fire has been extinguished.
Interstate-94 is currently closed in both directions in Kalamazoo County. Authorities estimate the interstate will be closed for at least another 12 hours.
Later in the day, another pileup occurred outside of Ann Arbor along US-23. Police there estimate about 40 vehicles to be involved.
This is a developing story. Stay with FOX 2 News for updates to this story.
Images and video used with permission from FOX 17 in Grand Rapids.