The accident happened on Gratiot between Eastgate and Glendale when she was trying to cross the street with two other girls.
The children were walking across the northbound lanes when the girl was struck at about 8:50 p.m.. The other two girls were not injured.
The driver is at the scene and is cooperating with police. Investigators say that alcohol and drugs do not appear to be a factor.
All travel lanes of northbound Gratiot are closed north of Frazho Road and alternate routes should be used.