The crew was at the scene of the fire early Wednesday morning on the 7,000 block of Meadow Avenue, which is near Eight Mile Road and Van Dyke Avenue.
One of the firefighters was treated on-scene and released. Two other firefighters were taken to the hospital, but have since been released and have returned home.
No one was believed to be in the home at the time of the fire, which spread quickly. No other injuries were reported. The cause wasn't immediately known.
A witness, James J. Crandall, shared video of the scene with FOX 2. You can watch in the video player above.