A 3-year-old and 6-year-old were killed in the crash and children ages 3, 5 and 7 were critically injured. One adult, a 23-year-old, was injured.
Two suspects were spotted by police and fled in a Chevrolet Camaro at 7:41 p.m. One of the suspects was seen with a gun. The car fled at a high rate of speed at about 70 to 80 miles per hour, Detroit Police Chief James Craig said.
The car crashed in the front yard of a house in the area of Frankfort and Nottingham.
Officers lost sight of the vehicle after pursuing it, and saw a plume of smoke in the distance. The Camaro had jumped a curb, crashing at a house.
"The officers saw two children laying in the roadway," Craig said. "They made efforts to resuscitate the children, then placed them in their police vehicle and they were transported.
"There were additional children also struck by this fleeing vehicle. They were immediately placed in a police vehicle and transported and are also being treated now."
Craig said his officers are struggling in the "aftermath of the situation."
One of the suspects was injured in the crash. Both suspects were arrested.
UPDATE: Chief Craig says the chase was called off after 62 seconds, when they realized the suspects were relentless and were driving through neighborhoods. A police source tells FOX 2's Roop Raj one cruiser was only traveling up to 50 mph when the chase was called off.