It will take place on Monday, April 6 from 9 to 11 a.m. at MotorCity Casino Hotel-Sound Board. Doors open at 8:30 a.m. Donations are $50 per person.
The lifelong Detroit Tigers fan will be in town to throw out the ceremonial first pitch at the team's home opener that afternoon.
The fundraiser will begin with introductions by NSO President and CEO Sheilah P. Clay and Board Chairman Ray C. Johnson.
Simmons will follow up his remarks with a Q&A session and a meet-and-greet with audience members.
Born in Detroit in 1955, Simmons studied voice and composition before working as a stage actor, eventually making his way to Broadway.
In 2015 he earned a Golden Globe and an Academy Award in the category of supporting actor for his role as harsh jazz bandleader Terence Fletcher in the 2014 film Whiplash.
In the film For the Love of the Game, Simmons played the role of Detroit Tigers' manager Frank Perry.
To purchase tickets to the fundraiser visit www.nso-mi.org.
NSO offers homeless recovery and mental health services, addiction treatment, early childhood education, youth programs, crisis intervention and suicide prevention to individuals and families in Wayne and Oakland counties.