Officials say the deployment happened earlier this month. They announced it Tuesday at Selfridge Air National Guard Base in Macomb County's Harrison Township, near Mount Clemens.
The airmen and A-10 Thunderbolt II "Warthogs" are from the 107th Fighter Squadron, 127th Aircraft Maintenance Squadron, 127th Maintenance Squadron and 127th Operations Support Squadron, as well as a few other units.
The Guard didn't give the exact location of the deployment in Southwest Asia but says the units are engaged in "daily missions" against the Islamic State group.
Brig. Gen. John D. Slocum says the deployment will last about six months.