WATCH: Izzo, Henry, Winston, Tillman & Goins talk yesterday's game & prepare for Minnesota

Unlike the grind of conference season, Michigan State coach Tom Izzo says, the fun of coaching in the NCAA Tournament is coming up with a game plan for an unfamiliar opponent, maybe one he and his team had never faced.

"You can run a play," Izzo said, "and not have the whole bench, cheerleaders and pep band yelling out what it's going to be."

That won't be the situation Saturday when the second-seeded Spartans (29-6) and No. 10 Minnesota (22-13) meet. It will be the first time two Big Ten teams have squared off in the tournament since 2000 and at the earliest point ever.

And guess what? The winner would face another Big Ten opponent next week in the East Region semifinals in Washington, D.C., if sixth-seeded Maryland beats third-seeded LSU on Saturday.

Michigan State, which held off Bradley's upset bid in the first round Thursday, has not made it to the second weekend of the tournament since 2015. That was the end of a run in which the Spartans reached the Sweet 16 seven times in eight years, including three Final Four appearances.

Minnesota is in the round of 32 for the first time since 2013 and trying to reach a regional semifinal for the first time since 1997. The '97 team made the Final Four, though that tournament appearance was later vacated because of NCAA rules violations.

"You're not going to hear me complain," said Gophers coach Richard Pitino, who is 2-6 against Izzo. "I don't care who we play. In order to go to a Sweet 16 you're never going to play easy games."

Six weeks ago, the Spartans dominated Minnesota 79-55 in East Lansing, Michigan, on a day Magic Johnson and his teammates were on hand to celebrate the 40th anniversary of winning the national championship. The Gophers had no answer for big man Nick Ward, who had 22 points; season scoring leaders Amir Coffey and Jordan Murphy combined for just nine points.

Minnesota comes into Saturday's game playing some of its best ball. The Gophers upset regular-season co-champion Purdue twice in 10 days, the second time in the Big Ten Tournament, and they were extremely sharp in their 86-76 first-round win over Louisville on Thursday.

"We're two completely different teams than we were a month and a half ago," Izzo said. "We didn't have Kenny Goins in that game. We did have Kyle Ahrens. We had Nick Ward full go and he played very well. On the other side of the coin, Amir Coffey wasn't a shadow of the player he is right now, and Gabe Kalscheur is playing much, much better."

According to NCAA director of media coordination and statistics David Worlock, the selection committee tries to avoid earlier-round pairings between teams from the same conference. The selection principles state that if the teams played only once during the season, including the conference tournament, they can play as early as the second round. Minnesota and Michigan State met only once.