Smoke could be seen billowing out of the front and top of the structure as heavy winds whipped a fire around the side of it.
The fire was in two parts of the building as of an hour ago. Flames could be seen covering one side of the building.
A staging area of the fire was set up on Grand River and Lothrop was established around 7 a.m. after reports of a fire catching at the building.
While several fire trucks and dozens of Detroit firefighters had surrounded the building, located at 7401 Grand River, climbing wind speeds that had expected to drop temperatures for much of the weekend was also playing a factor.
So far, one person was taken to a hospital with smoke inhalation being a factor.
The building is believed to be abandoned, having housed businesses in the past.