BALTIMORE - Renato Núñez homered in his return to Baltimore and the Detroit Tigers beat the Orioles 6-4 on Thursday as Miguel Cabrera sat out while one homer shy of 500.
Cabrera can now go for that milestone at home after the Tigers finished their road trip with a three-game sweep in Baltimore. Victor Reyes and Robbie Grossman also homered for Detroit.
The Orioles have lost eight in a row.
Matt Manning (3-5) allowed three runs and eight hits in six innings for Detroit, equaling the longest start of his debut season. Kyle Funkhouser followed in relief, and Michael Fulmer pitched two scoreless innings for his seventh save in nine chances.
Baltimore put men on first and second with one out in the ninth, but Cedric Mullins, who had three hits on the day, hit into a force play. Austin Hays then did the same to end it.
DJ Stewart hit solo homers in the fourth and sixth innings for the Orioles, but John Means (5-4) allowed six runs and eight hits in 4 1-3 innings.
Cabrera hit homer No. 499 on Wednesday night, and afterward manager A.J. Hinch said the 38-year-old slugger would play Thursday as well. But Hinch changed course and left Cabrera out of the lineup, citing the heat and the fact that rain delays had made for some long nights at the ballpark earlier in this series.
The temperature at game time Thursday was 97 degrees.
Detroit begins a three-game series at home against Cleveland on Friday night, then hosts the Angels for three games next week.
Núñez hit 50 homers for the Orioles from 2018-20, but he was released after last season. He hasn't played much for Detroit, but Cabrera's absence left an opening in the lineup, and Núñez hit the first of two two-run homers for the Tigers in the fourth. Reyes had the other to make it 5-1.
Grossman hit his 18th homer of the year in the fifth.
Mullins extended his hitting streak to 19 games with a first-inning single, and he eventually opened the scoring by coming home on a double steal. With men on first and third, Anthony Santander broke early for second, and as the Tigers tried to chase him down, Mullins broke for the plate and made it.
Jeimer Candelario tied it with an RBI double in the fourth.
Orioles: Baltimore reinstated RHP Tyler Wells (right wrist tendinitis) from the injured list.
Tyler Alexander (2-1) takes the mound for the Tigers against Cleveland's Zach Plesac (6-4).
The Orioles open a series at Boston on Friday night. Spenser Watkins (2-3) starts for Baltimore against Nick Pivetta (8-5).