Police said the male driver and a female passenger in the same vehicle both died after being shot. The man was pronounced dead at the scene while the woman was transported to the hospital and later declared dead.
The suspect from a separate vehicle fled on foot, police said.
However, when the driver had jumped the median wall, he was struck by a separate non-involved vehicle and killed. The non-involved driver was not hurt.
Two people were killed by gunfire while a third was struck by a vehicle not involved.
Police don't have a motive that resulted in the wild scene unfolding.
Law enforcement shut the road down to canvass the scene for evidence and speak with witnesses. A press release advised drivers to avoid the area and use local lanes only.
Both eastbound and westbound lanes were reopened around 4:30 Tuesday morning.
Michigan State Police were out until early Tuesday morning investigating a freeway shooting that ended in 3 dead