Michigan State Police said they received a call around 2:30 a.m. of a wrong-way driver from Romulus dispatch.
Later reports detailed the man had crashed head-on into another car, seriously injuring two people in the process.
The suspect driver was identified as a 42-year-old man. Police believe alcohol was a factor.
He also had his license suspended at the time of the crash.
He was driving a 1973 Buick when he struck a 2021 Kia.
The victims, a 19-year-old male driver and a 22-year-old female passenger were taken to a local hospital with serious injuries.
An investigation is pending a review of a medical examiner's report.
Lanes that were closed were reopened around 7:30 a.m.