The 54-year-old man died overnight, while a 67-year-old Redford Township woman is in extremely critical condition, Michigan State Police said.
Police were called to westbound I-96 near Livernois around 6:30 p.m. on reports of a vehicle that was on fire after a single-car crash.
According to police, the victims did not show obvious signs of being burned. They were taken to Henry Ford Hospital Detroit.
The investigation is ongoing.